diff --git a/extensions/cornerstone-dicom-rt/src/viewports/OHIFCornerstoneRTViewport.tsx b/extensions/cornerstone-dicom-rt/src/viewports/OHIFCornerstoneRTViewport.tsx
index 32f37970a..8d70b2701 100644
--- a/extensions/cornerstone-dicom-rt/src/viewports/OHIFCornerstoneRTViewport.tsx
+++ b/extensions/cornerstone-dicom-rt/src/viewports/OHIFCornerstoneRTViewport.tsx
@@ -51,6 +51,21 @@ function OHIFCornerstoneRTViewport(props: withAppTypes) {
   const referencedDisplaySetRef = useRef(null);
 
   const referencedDisplaySetInstanceUID = rtDisplaySet.referencedDisplaySetInstanceUID;
+  // If the referencedDisplaySetInstanceUID is not found, it means the RTStruct series is being
+  // launched without its corresponding referenced display set (e.g., the RTStruct series is launched using
+  // series launch /mode?StudyInstanceUIDs=&SeriesInstanceUID).
+  // In such cases, we attempt to handle this scenario gracefully by
+  // invoking a custom handler. Ideally, if a user tries to launch a series that isn't viewable,
+  // (eg.: we can prompt them with an explanation and provide a link to the full study).
+  if (!referencedDisplaySetInstanceUID) {
+    const missingReferenceDisplaySetHandler = customizationService.getCustomization(
+      'missingReferenceDisplaySetHandler'
+    );
+    const { handled } = missingReferenceDisplaySetHandler();
+    if (handled) {
+      return;
+    }
+  }
   const referencedDisplaySet = displaySetService.getDisplaySetByUID(
     referencedDisplaySetInstanceUID
   );
diff --git a/extensions/cornerstone-dicom-seg/src/viewports/OHIFCornerstoneSEGViewport.tsx b/extensions/cornerstone-dicom-seg/src/viewports/OHIFCornerstoneSEGViewport.tsx
index bd5e65dd9..b6d8e5259 100644
--- a/extensions/cornerstone-dicom-seg/src/viewports/OHIFCornerstoneSEGViewport.tsx
+++ b/extensions/cornerstone-dicom-seg/src/viewports/OHIFCornerstoneSEGViewport.tsx
@@ -54,6 +54,21 @@ function OHIFCornerstoneSEGViewport(props: withAppTypes) {
   const { viewports, activeViewportId } = viewportGrid;
 
   const referencedDisplaySetInstanceUID = segDisplaySet.referencedDisplaySetInstanceUID;
+  // If the referencedDisplaySetInstanceUID is not found, it means the SEG series is being
+  // launched without its corresponding referenced display set (e.g., the SEG series is launched using
+  // series launch /mode?StudyInstanceUIDs=&SeriesInstanceUID).
+  // In such cases, we attempt to handle this scenario gracefully by
+  // invoking a custom handler. Ideally, if a user tries to launch a series that isn't viewable,
+  // (eg.: we can prompt them with an explanation and provide a link to the full study).
+  if (!referencedDisplaySetInstanceUID) {
+    const missingReferenceDisplaySetHandler = customizationService.getCustomization(
+      'missingReferenceDisplaySetHandler'
+    );
+    const { handled } = missingReferenceDisplaySetHandler();
+    if (handled) {
+      return;
+    }
+  }
   const referencedDisplaySet = displaySetService.getDisplaySetByUID(
     referencedDisplaySetInstanceUID
   );
diff --git a/extensions/default/src/customizations/missingReferenceDisplaySetHandler.ts b/extensions/default/src/customizations/missingReferenceDisplaySetHandler.ts
new file mode 100644
index 000000000..001b9c472
--- /dev/null
+++ b/extensions/default/src/customizations/missingReferenceDisplaySetHandler.ts
@@ -0,0 +1,5 @@
+export default {
+  missingReferenceDisplaySetHandler: () => {
+    return Promise.resolve({ handled: false });
+  },
+};