diff --git a/extensions/dicom-rt/src/OHIFDicomRTStructSopClassHandler.js b/extensions/dicom-rt/src/OHIFDicomRTStructSopClassHandler.js
index 4f624cfa6..88f8402d4 100644
--- a/extensions/dicom-rt/src/OHIFDicomRTStructSopClassHandler.js
+++ b/extensions/dicom-rt/src/OHIFDicomRTStructSopClassHandler.js
@@ -15,7 +15,7 @@ const OHIFDicomRTStructSopClassHandler = {
   id: 'OHIFDicomRTStructSopClassHandler',
   type: MODULE_TYPES.SOP_CLASS_HANDLER,
   sopClassUIDs,
-  getDisplaySetFromSeries: function(
+  getDisplaySetFromSeries: function (
     series,
     study,
     dicomWebClient,
@@ -71,11 +71,11 @@ const OHIFDicomRTStructSopClassHandler = {
       }
     }
 
-    rtStructDisplaySet.getSourceDisplaySet = function(studies) {
+    rtStructDisplaySet.getSourceDisplaySet = function (studies) {
       return getSourceDisplaySet(studies, rtStructDisplaySet);
     };
 
-    rtStructDisplaySet.load = function(referencedDisplaySet, studies) {
+    rtStructDisplaySet.load = function (referencedDisplaySet, studies) {
       return loadRTStruct(
         rtStructDisplaySet,
         referencedDisplaySet,
diff --git a/extensions/dicom-rt/src/components/RTPanel/RTPanel.js b/extensions/dicom-rt/src/components/RTPanel/RTPanel.js
index 504089a04..5d9c9b98b 100644
--- a/extensions/dicom-rt/src/components/RTPanel/RTPanel.js
+++ b/extensions/dicom-rt/src/components/RTPanel/RTPanel.js
@@ -79,6 +79,8 @@ const RTPanel = ({
    * without subscribing to external events.
    */
   useEffect(() => {
+    updateStructureSets();
+
     document.addEventListener('extensiondicomrtrtloaded', updateStructureSets);
 
     return () => {
diff --git a/extensions/dicom-rt/src/loadRTStruct.js b/extensions/dicom-rt/src/loadRTStruct.js
index 42fd24d5c..a5323b7f2 100644
--- a/extensions/dicom-rt/src/loadRTStruct.js
+++ b/extensions/dicom-rt/src/loadRTStruct.js
@@ -96,6 +96,11 @@ export default async function loadRTStruct(
           imageIdSopInstanceUidPairs
         );
       const imageId = _getImageId(imageIdSopInstanceUidPairs, sopInstanceUID);
+
+      if (!imageId) {
+        continue;
+      }
+
       const imageIdSpecificToolData = _getOrCreateImageIdSpecificToolData(
         toolState,
         imageId,
@@ -294,7 +299,7 @@ const _getImageId = (imageIdSopInstanceUidPairs, sopInstanceUID) => {
       imageIdSopInstanceUidPairsEntry.sopInstanceUID === sopInstanceUID
   );
 
-  return imageIdSopInstanceUidPairsEntry.imageId;
+  return imageIdSopInstanceUidPairsEntry ? imageIdSopInstanceUidPairsEntry.imageId : null;
 };
 
 function _getImageIdSopInstanceUidPairsForDisplaySet(
diff --git a/extensions/vtk/src/toolbarComponents/VTKMPRToolbarButton.js b/extensions/vtk/src/toolbarComponents/VTKMPRToolbarButton.js
index 7f90fcd71..7486b9b77 100644
--- a/extensions/vtk/src/toolbarComponents/VTKMPRToolbarButton.js
+++ b/extensions/vtk/src/toolbarComponents/VTKMPRToolbarButton.js
@@ -41,14 +41,17 @@ const _isDisplaySetReconstructable = (viewportSpecificData = {}, activeViewportI
   // A better heuristic would be checking 4D tags, e.g. the presence of multiple TemporalPositionIdentifier values.
   // However, some studies (e.g. https://github.com/OHIF/Viewers/issues/2113) do not have such tags.
 
-  for (let ii = 0; ii < displaySet.numImageFrames; ++ii){
-    const imageIdControl = displaySet.images[ii].getImageId()
+  for (let ii = 0; ii < displaySet.numImageFrames; ++ii) {
+    const image = displaySet.images[ii];
+    if (!image) continue;
+
+    const imageIdControl = image.getImageId()
     const instanceMetadataControl = cornerstone.metaData.get('instance', imageIdControl)
 
     if (!instanceMetadataControl ||
       instanceMetadataControl === undefined ||
       !instanceMetadataControl.ImagePositionPatient ||
-      instanceMetadataControl.ImagePositionPatient === undefined ) {
+      instanceMetadataControl.ImagePositionPatient === undefined) {
       // if ImagePositionPatient is missing, skip the 4D datasets check.
       // do not return false, because it could be a 3D dataset.
       continue;
@@ -58,8 +61,11 @@ const _isDisplaySetReconstructable = (viewportSpecificData = {}, activeViewportI
     let yImagePositionPatientControl = instanceMetadataControl.ImagePositionPatient[1];
     let zImagePositionPatientControl = instanceMetadataControl.ImagePositionPatient[2];
 
-    for (let jj = ii + 1; jj < displaySet.numImageFrames; ++jj){
-      const imageId = displaySet.images[jj].getImageId()
+    for (let jj = ii + 1; jj < displaySet.numImageFrames; ++jj) {
+      const image = displaySet.images[jj];
+      if (!image) continue;
+
+      const imageId = image.getImageId()
       const instanceMetadata = cornerstone.metaData.get('instance', imageId)
 
       if (!instanceMetadata ||
@@ -76,8 +82,8 @@ const _isDisplaySetReconstructable = (viewportSpecificData = {}, activeViewportI
       let zImagePositionPatient = instanceMetadata.ImagePositionPatient[2];
 
       if (xImagePositionPatientControl === xImagePositionPatient &&
-          yImagePositionPatientControl === yImagePositionPatient &&
-          zImagePositionPatientControl === zImagePositionPatient){
+        yImagePositionPatientControl === yImagePositionPatient &&
+        zImagePositionPatientControl === zImagePositionPatient) {
         return false;
       }
     }