diff --git a/extensions/default/src/commandsModule.ts b/extensions/default/src/commandsModule.ts
index 238cd37ff..230a82943 100644
--- a/extensions/default/src/commandsModule.ts
+++ b/extensions/default/src/commandsModule.ts
@@ -23,6 +23,11 @@ export type HangingProtocolParams = {
   stageId?: string;
 };
 
+export type UpdateViewportDisplaySetParams = {
+  direction: number;
+  excludeNonImageModalities?: boolean;
+};
+
 /**
  * Determine if a command is a hanging protocol one.
  * For now, just use the two hanging protocol commands that are in this
@@ -541,6 +546,130 @@ const commandsModule = ({
         overlays.item(i).classList.toggle('hidden');
       }
     },
+
+    scrollActiveThumbnailIntoView: () => {
+      const { activeViewportIndex, viewports } = viewportGridService.getState();
+
+      if (
+        !viewports ||
+        activeViewportIndex < 0 ||
+        activeViewportIndex > viewports.length - 1
+      ) {
+        return;
+      }
+
+      const activeViewport = viewports[activeViewportIndex];
+      const activeDisplaySetInstanceUID =
+        activeViewport.displaySetInstanceUIDs[0];
+
+      const thumbnailList = document.querySelector('#ohif-thumbnail-list');
+
+      if (!thumbnailList) {
+        return;
+      }
+
+      const thumbnailListBounds = thumbnailList.getBoundingClientRect();
+
+      const thumbnail = document.querySelector(
+        `#thumbnail-${activeDisplaySetInstanceUID}`
+      );
+
+      if (!thumbnail) {
+        return;
+      }
+
+      const thumbnailBounds = thumbnail.getBoundingClientRect();
+
+      // This only handles a vertical thumbnail list.
+      if (
+        thumbnailBounds.top >= thumbnailListBounds.top &&
+        thumbnailBounds.top <= thumbnailListBounds.bottom
+      ) {
+        return;
+      }
+
+      thumbnail.scrollIntoView({ behavior: 'smooth' });
+    },
+
+    updateViewportDisplaySet: ({
+      direction,
+      excludeNonImageModalities,
+    }: UpdateViewportDisplaySetParams) => {
+      const nonImageModalities = [
+        'SR',
+        'SEG',
+        'SM',
+        'RTSTRUCT',
+        'RTPLAN',
+        'RTDOSE',
+      ];
+
+      // Sort the display sets as per the hanging protocol service viewport/display set scoring system.
+      // The thumbnail list uses the same sorting.
+      const dsSortFn = hangingProtocolService.getDisplaySetSortFunction();
+      const currentDisplaySets = [...displaySetService.activeDisplaySets];
+
+      currentDisplaySets.sort(dsSortFn);
+
+      const { activeViewportIndex, viewports } = viewportGridService.getState();
+
+      const { displaySetInstanceUIDs } = viewports[activeViewportIndex];
+
+      const activeDisplaySetIndex = currentDisplaySets.findIndex(displaySet =>
+        displaySetInstanceUIDs.includes(displaySet.displaySetInstanceUID)
+      );
+
+      let displaySetIndexToShow: number;
+
+      for (
+        displaySetIndexToShow = activeDisplaySetIndex + direction;
+        displaySetIndexToShow > -1 &&
+        displaySetIndexToShow < currentDisplaySets.length;
+        displaySetIndexToShow += direction
+      ) {
+        if (
+          !excludeNonImageModalities ||
+          !nonImageModalities.includes(
+            currentDisplaySets[displaySetIndexToShow].Modality
+          )
+        ) {
+          break;
+        }
+      }
+
+      if (
+        displaySetIndexToShow < 0 ||
+        displaySetIndexToShow >= currentDisplaySets.length
+      ) {
+        return;
+      }
+
+      const { displaySetInstanceUID } = currentDisplaySets[
+        displaySetIndexToShow
+      ];
+
+      let updatedViewports = [];
+
+      try {
+        updatedViewports = hangingProtocolService.getViewportsRequireUpdate(
+          activeViewportIndex,
+          displaySetInstanceUID
+        );
+      } catch (error) {
+        console.warn(error);
+        uiNotificationService.show({
+          title: 'Navigate Viewport Display Set',
+          message:
+            'The requested display sets could not be added to the viewport due to a mismatch in the Hanging Protocol rules.',
+          type: 'info',
+          duration: 3000,
+        });
+      }
+
+      viewportGridService.setDisplaySetsForViewports(updatedViewports);
+
+      setTimeout(() => actions.scrollActiveThumbnailIntoView(), 0);
+    },
   };
 
   const definitions = {
@@ -598,6 +727,11 @@ const commandsModule = ({
     openDICOMTagViewer: {
       commandFn: actions.openDICOMTagViewer,
     },
+    updateViewportDisplaySet: {
+      commandFn: actions.updateViewportDisplaySet,
+      storeContexts: [],
+      options: {},
+    },
   };
 
   return {
diff --git a/extensions/measurement-tracking/src/panels/PanelStudyBrowserTracking/PanelStudyBrowserTracking.tsx b/extensions/measurement-tracking/src/panels/PanelStudyBrowserTracking/PanelStudyBrowserTracking.tsx
index 9cc9ab2a7..99eaa6a5e 100644
--- a/extensions/measurement-tracking/src/panels/PanelStudyBrowserTracking/PanelStudyBrowserTracking.tsx
+++ b/extensions/measurement-tracking/src/panels/PanelStudyBrowserTracking/PanelStudyBrowserTracking.tsx
@@ -1,6 +1,6 @@
 import React, { useState, useEffect } from 'react';
 import PropTypes from 'prop-types';
-import { utils } from '@ohif/core';
+import { HangingProtocolService, utils } from '@ohif/core';
 import {
   StudyBrowser,
   useImageViewer,
@@ -292,7 +292,8 @@ function PanelStudyBrowserTracking({
   const tabs = _createStudyBrowserTabs(
     StudyInstanceUIDs,
     studyDisplayList,
-    displaySets
+    displaySets,
+    hangingProtocolService
   );
 
   // TODO: Should not fire this on "close"
@@ -601,7 +602,8 @@ function _getComponentType(Modality) {
 function _createStudyBrowserTabs(
   primaryStudyInstanceUIDs,
   studyDisplayList,
-  displaySets
+  displaySets,
+  hangingProtocolService
 ) {
   const primaryStudies = [];
   const recentStudies = [];
@@ -615,9 +617,8 @@ function _createStudyBrowserTabs(
     );
 
     // Sort them
-    const sortedDisplaySetsForStudy = utils.sortBySeriesDate(
-      displaySetsForStudy
-    );
+    const dsSortFn = hangingProtocolService.getDisplaySetSortFunction();
+    displaySetsForStudy.sort(dsSortFn);
 
     /* Sort by series number, then by series date
       displaySetsForStudy.sort((a, b) => {
diff --git a/platform/core/src/defaults/hotkeyBindings.js b/platform/core/src/defaults/hotkeyBindings.js
index 75023247c..4c12e2179 100644
--- a/platform/core/src/defaults/hotkeyBindings.js
+++ b/platform/core/src/defaults/hotkeyBindings.js
@@ -76,18 +76,24 @@ const bindings = [
     keys: ['left'],
     isEditable: true,
   },
-  // {
-  //   commandName: 'nextViewportDisplaySet',
-  //   label: 'Next Series',
-  //   keys: ['pageup'],
-  //   isEditable: true,
-  // },
-  // {
-  //   commandName: 'previousViewportDisplaySet',
-  //   label: 'Previous Series',
-  //   keys: ['pagedown'],
-  //   isEditable: true,
-  // },
+  {
+    commandName: 'updateViewportDisplaySet',
+    commandOptions: {
+      direction: -1,
+    },
+    label: 'Previous Series',
+    keys: ['pageup'],
+    isEditable: true,
+  },
+  {
+    commandName: 'updateViewportDisplaySet',
+    commandOptions: {
+      direction: 1,
+    },
+    label: 'Next Series',
+    keys: ['pagedown'],
+    isEditable: true,
+  },
   {
     commandName: 'nextStage',
     context: 'DEFAULT',
diff --git a/platform/core/src/services/HangingProtocolService/HangingProtocolService.ts b/platform/core/src/services/HangingProtocolService/HangingProtocolService.ts
index 3b6c540c2..4d3f72df0 100644
--- a/platform/core/src/services/HangingProtocolService/HangingProtocolService.ts
+++ b/platform/core/src/services/HangingProtocolService/HangingProtocolService.ts
@@ -1033,6 +1033,23 @@ export default class HangingProtocolService extends PubSubService {
     return this._matchViewport(useViewport, options);
   }
 
+  /**
+   * Gets a sort function that is consistent with the display set sorting performed
+   * to match display sets to viewports.
+   * @returns a display set sort function
+   */
+  public getDisplaySetSortFunction(): (
+    displaySetA: IDisplaySet,
+    displaySetB: IDisplaySet
+  ) => number {
+    return (displaySetA, displaySetB) => {
+      const seriesA = this._getSeriesSortInfoForDisplaySetSort(displaySetA);
+      const seriesB = this._getSeriesSortInfoForDisplaySetSort(displaySetB);
+
+      return sortBy(this._getSeriesFieldForDisplaySetSort())(seriesA, seriesB);
+    };
+  }
+
   /**
    * Updates the viewports with the selected protocol stage.
    */
@@ -1461,7 +1478,7 @@ export default class HangingProtocolService extends PubSubService {
           sortingInfo: {
             score: totalMatchScore,
             study: study.StudyInstanceUID,
-            series: parseInt(displaySet.SeriesNumber),
+            ...this._getSeriesSortInfoForDisplaySetSort(displaySet),
           },
         };
 
@@ -1484,9 +1501,7 @@ export default class HangingProtocolService extends PubSubService {
         name: 'study',
         reverse: true,
       },
-      {
-        name: 'series',
-      }
+      this._getSeriesFieldForDisplaySetSort()
     );
     matchingScores.sort((a, b) =>
       sortingFunction(a.sortingInfo, b.sortingInfo)
@@ -1506,6 +1521,19 @@ export default class HangingProtocolService extends PubSubService {
     };
   }
 
+  private _getSeriesSortInfoForDisplaySetSort(displaySet) {
+    return {
+      [this._getSeriesFieldForDisplaySetSort().name]:
+        displaySet.SeriesNumber != null
+          ? parseInt(displaySet.SeriesNumber)
+          : parseInt(displaySet.seriesNumber),
+    };
+  }
+
+  private _getSeriesFieldForDisplaySetSort() {
+    return { name: 'series' };
+  }
+
   /**
    * Check if the next stage is available
    * @return {Boolean} True if next stage is available or false otherwise
diff --git a/platform/ui/src/components/ThumbnailList/ThumbnailList.tsx b/platform/ui/src/components/ThumbnailList/ThumbnailList.tsx
index df2047cad..b1cb06416 100644
--- a/platform/ui/src/components/ThumbnailList/ThumbnailList.tsx
+++ b/platform/ui/src/components/ThumbnailList/ThumbnailList.tsx
@@ -12,7 +12,10 @@ const ThumbnailList = ({
   activeDisplaySetInstanceUIDs = [],
 }) => {
   return (
-    <div className="py-3 bg-black overflow-y-hidden ohif-scrollbar study-min-height">
+    <div
+      id="ohif-thumbnail-list"
+      className="py-3 bg-black overflow-y-hidden ohif-scrollbar study-min-height"
+    >
       {thumbnails.map(
         ({
           displaySetInstanceUID,