diff --git a/platform/viewer/cypress/integration/common/OHIFCornerstoneHotkeys.spec.js b/platform/viewer/cypress/integration/common/OHIFCornerstoneHotkeys.spec.js
new file mode 100644
index 000000000..f525b61a2
--- /dev/null
+++ b/platform/viewer/cypress/integration/common/OHIFCornerstoneHotkeys.spec.js
@@ -0,0 +1,153 @@
+describe('OHIF Cornerstone Hotkeys', () => {
+  before(() => {
+    cy.openStudy('MISTER^MR');
+    cy.waitDicomImage();
+    cy.expectMinimumThumbnails(3);
+  });
+
+  beforeEach(() => {
+    cy.initCornerstoneToolsAliases();
+    cy.initCommonElementsAliases();
+    cy.resetViewport();
+  });
+
+  it('checks if hotkeys "R" and "L" can rotate the image', () => {
+    // Hotkey R
+    cy.get('body').type('R');
+    cy.get('@viewportInfoMidLeft').should('contains.text', 'P');
+    cy.get('@viewportInfoMidTop').should('contains.text', 'R');
+    // Hotkey L
+    cy.get('body').type('L');
+    cy.get('@viewportInfoMidLeft').should('contains.text', 'R');
+    cy.get('@viewportInfoMidTop').should('contains.text', 'A');
+  });
+
+  it('checks if hotkeys "ArrowUp" and "ArrowDown" can navigate in the stack', () => {
+    // Hotkey ArrowDown
+    cy.get('body').type('{downarrow}');
+    cy.get('@viewportInfoBottomLeft').should('contains.text', 'Img: 2 2/26');
+    // Hotkey ArrowUp
+    cy.get('body').type('{uparrow}');
+    cy.get('@viewportInfoBottomLeft').should('contains.text', 'Img: 1 1/26');
+  });
+
+  it('checks if hotkeys "V" and "H" can flip the image', () => {
+    // Hotkey V
+    cy.get('body').type('V');
+    cy.get('@viewportInfoMidLeft').should('contains.text', 'L');
+    cy.get('@viewportInfoMidTop').should('contains.text', 'A');
+    // Hotkey H
+    cy.get('body').type('H');
+    cy.get('@viewportInfoMidLeft').should('contains.text', 'L');
+    cy.get('@viewportInfoMidTop').should('contains.text', 'P');
+  });
+
+  it('checks if hotkey "I" can invert the image', () => {
+    // Hotkey I
+    cy.get('body').type('I');
+    // Visual comparison
+    cy.screenshot();
+    cy.percyCanvasSnapshot('Hotkey I - invert image');
+  });
+
+  it('checks if hotkeys "+", "-" and "=" can zoom in, out and fit to viewport', () => {
+    // Hotkey +
+    cy.get('body').type('+++'); // Press hotkey 3 times
+    cy.get('@viewportInfoBottomRight').should('contains.text', 'Zoom: 256%');
+    // Hotkey -
+    cy.get('body').type('-');
+    cy.get('@viewportInfoBottomRight').should('contains.text', 'Zoom: 241%');
+    // Hotkey =
+    cy.get('body').type('=');
+    cy.get('@viewportInfoBottomRight').should('contains.text', 'Zoom: 211%');
+  });
+
+  it('checks if hotkey "SPACEBAR" can reset the image', () => {
+    // Press multiples hotkeys
+    cy.get('body').type('V+++I');
+    cy.get('@viewportInfoMidLeft').should('contains.text', 'L');
+    cy.get('@viewportInfoMidTop').should('contains.text', 'A');
+    cy.get('@viewportInfoBottomRight').should('contains.text', 'Zoom: 256%');
+
+    // Hotkey SPACEBAR
+    cy.get('body').type(' ');
+    cy.get('@viewportInfoMidLeft').should('contains.text', 'R');
+    cy.get('@viewportInfoMidTop').should('contains.text', 'A');
+    cy.get('@viewportInfoBottomRight').should('contains.text', 'Zoom: 211%');
+
+    // Visual comparison to make sure the 'inverted' image was reset
+    cy.screenshot();
+    cy.percyCanvasSnapshot('Hotkey SPACEBAR - Reset Image');
+  });
+
+  it('uses hotkeys "RightArrow" and "LeftArrow" to navigate between multiple viewports', () => {
+    //Click on Layout button
+    cy.get('@layoutBtn').click();
+    //Select 3 viewports
+    cy.get('tbody > :nth-child(1) > :nth-child(3)').click();
+
+    // Press multiples hotkeys on viewport #1
+    cy.get('body').type('VL+++I');
+    cy.get('@viewportInfoMidLeft').should('contains.text', 'A');
+    cy.get('@viewportInfoMidTop').should('contains.text', 'R');
+    cy.get('@viewportInfoBottomRight').should('contains.text', 'Zoom: 134%');
+
+    // Hotkey RightArrow: Move to next viewport
+    cy.get('body').type('{rightarrow}');
+
+    // Get overlay information from viewport #2
+    cy.get(
+      ':nth-child(2) > .viewport-wrapper > .viewport-element > .ViewportOrientationMarkers.noselect > .top-mid.orientation-marker'
+    ).as('viewport2InfoMidTop');
+    cy.get(
+      ':nth-child(2) > .viewport-wrapper > .viewport-element > .ViewportOrientationMarkers.noselect > .left-mid.orientation-marker'
+    ).as('viewport2InfoMidLeft');
+    cy.get(
+      ':nth-child(2) > .viewport-wrapper > .viewport-element > .ViewportOverlay > div.bottom-right.overlay-element > div'
+    ).as('viewport2InfoBottomRight');
+
+    // Press multiples hotkeys on viewport #2
+    cy.get('body').type('RR++H+++I');
+    cy.get('@viewport2InfoMidLeft').should('contains.text', 'P');
+    cy.get('@viewport2InfoMidTop').should('contains.text', 'H');
+    cy.get('@viewport2InfoBottomRight').should('contains.text', 'Zoom: 120%');
+
+    // Hotkey LeftArrow: Move to previous viewport
+    cy.get('body').type('{leftarrow}');
+
+    // Hotkey SPACEBAR: Reset viewport #1
+    cy.get('body').type(' ');
+    cy.get('@viewportInfoMidLeft').should('contains.text', 'R');
+    cy.get('@viewportInfoMidTop').should('contains.text', 'A');
+    cy.get('@viewportInfoBottomRight').should('contains.text', 'Zoom: 89%');
+
+    // Hotkey RightArrow: Move to next viewport
+    cy.get('body').type('{rightarrow}');
+
+    // Hotkey SPACEBAR: Reset viewport #2
+    cy.get('body').type(' ');
+    cy.get('@viewport2InfoMidLeft').should('contains.text', 'A');
+    cy.get('@viewport2InfoMidTop').should('contains.text', 'H');
+    cy.get('@viewport2InfoBottomRight').should('contains.text', 'Zoom: 45%');
+  });
+
+  //TO-DO: This test is blocked by issue #1095 (https://github.com/OHIF/Viewers/issues/1095)
+  //Once issue is fixed, this test can be uncommented
+  // it('checks if hotkey "Z" activates zoom tool', () => {
+  //   // Hotkey Z
+  //   cy.get('body').type('Z');
+  //   // Verify if icon is active on toolbar
+  //   cy.get('@zoomBtn').should('have.class', 'active');
+  // });
+
+  //TO-DO: This test is blocked by issue #1095 (https://github.com/OHIF/Viewers/issues/1095)
+  //Once issue is fixed, this test can be uncommented
+  // it('checks if hotkeys "PageDown" and "PageUp" can navigate in the series thumbnails', () => {
+  //   // Hotkey PageDown
+  //   cy.get('body').type('{pagedown}{pagedown}'); // press hotkey twice
+  //   cy.get('@viewportInfoBottomLeft').should('contains.text', 'Ser: 3');
+  //   // Hotkey PageUp
+  //   cy.get('body').type('{pageup}');
+  //   cy.get('@viewportInfoBottomLeft').should('contains.text', 'Ser: 2');
+  // });
+});
diff --git a/platform/viewer/cypress/integration/common/OHIFCornerstoneToolbar.spec.js b/platform/viewer/cypress/integration/common/OHIFCornerstoneToolbar.spec.js
index 643d74e81..380622430 100644
--- a/platform/viewer/cypress/integration/common/OHIFCornerstoneToolbar.spec.js
+++ b/platform/viewer/cypress/integration/common/OHIFCornerstoneToolbar.spec.js
@@ -66,7 +66,7 @@ describe('OHIF Cornerstone Toolbar', () => {
   });
 
   it('checks if Zoom tool will zoom in/out an image in the viewport', () => {
-    //Click on button and vefiry if icon is active on toolbar
+    //Click on button and verify if icon is active on toolbar
     cy.get('@zoomBtn')
       .click()
       .then($zoomBtn => {
diff --git a/platform/viewer/cypress/support/aliases.js b/platform/viewer/cypress/support/aliases.js
index ec9a246eb..1f22d200f 100644
--- a/platform/viewer/cypress/support/aliases.js
+++ b/platform/viewer/cypress/support/aliases.js
@@ -30,6 +30,8 @@ export function initCommonElementsAliases() {
   cy.get('div.ViewportOverlay > div.bottom-right.overlay-element > div').as(
     'viewportInfoBottomRight'
   );
+  cy.get('.left-mid.orientation-marker').as('viewportInfoMidLeft');
+  cy.get('.top-mid.orientation-marker').as('viewportInfoMidTop');
 }
 
 //Creating aliases for Routes