diff --git a/extensions/cornerstone/src/init.tsx b/extensions/cornerstone/src/init.tsx
index 4a07f4e63..98f905ab9 100644
--- a/extensions/cornerstone/src/init.tsx
+++ b/extensions/cornerstone/src/init.tsx
@@ -166,7 +166,7 @@ export default async function init({
     prefetch: appConfig?.maxNumRequests?.prefetch || 10,
   };
 
-  initWADOImageLoader(userAuthenticationService, appConfig);
+  initWADOImageLoader(userAuthenticationService, appConfig, extensionManager);
 
   /* Measurement Service */
   this.measurementServiceSource = connectToolsToMeasurementService(
diff --git a/extensions/cornerstone/src/initWADOImageLoader.js b/extensions/cornerstone/src/initWADOImageLoader.js
index c21326b5f..f5ac1a8ab 100644
--- a/extensions/cornerstone/src/initWADOImageLoader.js
+++ b/extensions/cornerstone/src/initWADOImageLoader.js
@@ -35,7 +35,8 @@ function initWebWorkers(appConfig) {
 
 export default function initWADOImageLoader(
   userAuthenticationService,
-  appConfig
+  appConfig,
+  extensionManager
 ) {
   dicomImageLoader.external.cornerstone = cornerstone;
   dicomImageLoader.external.dicomParser = dicomParser;
@@ -54,6 +55,32 @@ export default function initWADOImageLoader(
       // we should set this flag to false.
       convertFloatPixelDataToInt: false,
     },
+    beforeSend: function (xhr) {
+      const headers = userAuthenticationService.getAuthorizationHeader();
+      const sourceConfig = extensionManager.getActiveDataSource()[0].getConfig()
+      const acceptHeader = generateAcceptHeader(sourceConfig.acceptHeader, sourceConfig.omitQuotationForMultipartRequest)
+
+      // Request:
+      // JPEG-LS Lossless (1.2.840.10008.1.2.4.80) if available, otherwise accept
+      // whatever transfer-syntax the origin server provides.
+      // For now we use image/jls and image/x-jls because some servers still use the old type
+      // http://dicom.nema.org/medical/dicom/current/output/html/part18.html
+      const xhrRequestHeaders = {
+        Accept: acceptHeader
+        /*
+        appConfig.omitQuotationForMultipartRequest
+          ? 'multipart/related; type=application/octet-stream'
+          : 'multipart/related; type="application/octet-stream"',
+        // 'multipart/related; type="image/x-jls", multipart/related; type="image/jls"; transfer-syntax="1.2.840.10008.1.2.4.80", multipart/related; type="image/x-jls", multipart/related; type="application/octet-stream"; transfer-syntax=*',
+      */
+      };
+
+      if (headers) {
+        Object.assign(xhrRequestHeaders, headers);
+      }
+
+      return xhrRequestHeaders;
+    },
     errorInterceptor: error => {
       errorHandler.getHTTPErrorHandler(error);
     },
@@ -62,6 +89,34 @@ export default function initWADOImageLoader(
   initWebWorkers(appConfig);
 }
 
+const generateAcceptHeader = (configAcceptHeader = [], omitQuotationForMultipartRequest = false) => {
+  let acceptHeader = []
+  if (configAcceptHeader.length === 0) {
+    acceptHeader.push('multipart/related; type=application/octet-stream')
+  } else {
+    acceptHeader = configAcceptHeader
+  }
+
+  if (!omitQuotationForMultipartRequest) {
+    //need to add quotation for each mime type of each accept entry
+    acceptHeader = acceptHeader.map(accept => {
+      let mimes = accept.split("; ")
+      let newMimes = mimes.map(mime => {
+        if (mime.startsWith('type=')) {
+          const quotedParam = 'type=' + '"' + mime.substring(5, mime.length) + '"'
+          return quotedParam
+        } else {
+          return mime
+        }
+      })
+      return newMimes.join(';')
+    })
+  }
+
+  return acceptHeader
+
+}
+
 export function destroy() {
   // Note: we don't want to call .terminate on the webWorkerManager since
   // that resets the config
diff --git a/extensions/default/src/DicomWebDataSource/index.js b/extensions/default/src/DicomWebDataSource/index.js
index d1e5ef472..5c31ec042 100644
--- a/extensions/default/src/DicomWebDataSource/index.js
+++ b/extensions/default/src/DicomWebDataSource/index.js
@@ -66,15 +66,8 @@ function createDicomWebApi(dicomWebConfig, userAuthenticationService) {
 
   const dicomWebConfigCopy = JSON.parse(JSON.stringify(dicomWebConfig));
 
-  //If accept header is not specified, set as multipart
-  let formattedAcceptHeader = acceptHeader ?? []
-  if (formattedAcceptHeader.length === 0) {
-    formattedAcceptHeader = ['multipart/related']
-  }
-
-  if (!omitQuotationForMultipartRequest) {
-    formattedAcceptHeader.forEach((header) => '"' + header + '"')
-  }
+  //Generate accept header depending on config params
+  let formattedAcceptHeader = generateAcceptHeader(acceptHeader, omitQuotationForMultipartRequest)
 
   const authHeaders = userAuthenticationService.getAuthorizationHeader()
 
@@ -98,8 +91,7 @@ function createDicomWebApi(dicomWebConfig, userAuthenticationService) {
     singlepart,
     headers: {
       ...xhrRequestHeaders,
-      //Serialize Accept header
-      Accept: formattedAcceptHeader.join('; ')
+      Accept: formattedAcceptHeader
     },
     errorInterceptor: errorHandler.getHTTPErrorHandler(),
   };
@@ -526,4 +518,32 @@ function createDicomWebApi(dicomWebConfig, userAuthenticationService) {
   return IWebApiDataSource.create(implementation);
 }
 
+const generateAcceptHeader = (configAcceptHeader = [], omitQuotationForMultipartRequest = false) => {
+  let acceptHeader = []
+  if (configAcceptHeader.length === 0) {
+    acceptHeader.push('multipart/related; type=application/octet-stream')
+  } else {
+    acceptHeader = configAcceptHeader
+  }
+
+  if (!omitQuotationForMultipartRequest) {
+    //need to add quotation for each mime type of each accept entry
+    acceptHeader = acceptHeader.map(accept => {
+      let mimes = accept.split("; ")
+      let newMimes = mimes.map(mime => {
+        if (mime.startsWith('type=')) {
+          const quotedParam = 'type=' + '"' + mime.substring(5, mime.length) + '"'
+          return quotedParam
+        } else {
+          return mime
+        }
+      })
+      return newMimes.join(';')
+    })
+  }
+
+  return acceptHeader
+
+}
+
 export { createDicomWebApi };
diff --git a/platform/docs/docs/configuration/configurationFiles.md b/platform/docs/docs/configuration/configurationFiles.md
index 5a6f16e55..21239030c 100644
--- a/platform/docs/docs/configuration/configurationFiles.md
+++ b/platform/docs/docs/configuration/configurationFiles.md
@@ -112,7 +112,7 @@ Here are a list of some options available:
 - `maxNumberOfWebWorkers`: The maximum number of web workers to use for
   decoding. Defaults to minimum of `navigator.hardwareConcurrency` and
   what is specified by `maxNumberOfWebWorkers`. Some windows machines require smaller values.
-- `requestTransferSyntaxUID`  : Request for a specific TS to the DICOM archive ex : 1.2.840.10008.1.2.4.80
+- `acceptHeader` : accept header to request specific dicom transfer syntax ex : [ 'multipart/related; type=image/jls; q=1', 'multipart/related; type=application/octet-stream; q=0.1' ]
 - `omitQuotationForMultipartRequest`: Some servers (e.g., .NET) require the `multipart/related` request to be sent without quotation marks. Defaults to `false`. If your server doesn't require this, then setting this flag to `true` might improve performance (by removing the need for preflight requests). Also note that
 if auth headers are used, a preflight request is required.
 - `maxNumRequests`: The maximum number of requests to allow in parallel. It is an object with keys of `interaction`, `thumbnail`, and `prefetch`. You can specify a specific number for each type.