diff --git a/extensions/default/src/DicomWebDataSource/utils/fixBulkDataURI.ts b/extensions/default/src/DicomWebDataSource/utils/fixBulkDataURI.ts
index 953a7e4ce..49c622916 100644
--- a/extensions/default/src/DicomWebDataSource/utils/fixBulkDataURI.ts
+++ b/extensions/default/src/DicomWebDataSource/utils/fixBulkDataURI.ts
@@ -20,26 +20,36 @@ function fixBulkDataURI(value, instance, dicomWebConfig) {
   // in case of the relative path, make it absolute. The current DICOM standard says
   // the bulkdataURI is relative to the series. However, there are situations where
   // it can be relative to the study too
-  const { BulkDataURI } = value;
+  let { BulkDataURI } = value;
+  const { bulkDataURI: uriConfig = {} } = dicomWebConfig;
+
+  // Handle incorrectly prefixed origins
+  const { startsWith, prefixWith = '' } = uriConfig;
+  if (startsWith && BulkDataURI.startsWith(startsWith)) {
+    BulkDataURI = prefixWith + BulkDataURI.substring(startsWith.length);
+    value.BulkDataURI = BulkDataURI;
+  }
+
   if (!BulkDataURI.startsWith('http') && !value.BulkDataURI.startsWith('/')) {
     const { StudyInstanceUID, SeriesInstanceUID } = instance;
     const isInstanceStart = BulkDataURI.startsWith('instances/') || BulkDataURI.startsWith('../');
     if (
       BulkDataURI.startsWith('series/') ||
       BulkDataURI.startsWith('bulkdata/') ||
-      (dicomWebConfig.bulkDataURI?.relativeResolution === 'studies' && isInstanceStart)
+      (uriConfig.relativeResolution === 'studies' && isInstanceStart)
     ) {
       value.BulkDataURI = `${dicomWebConfig.wadoRoot}/studies/${StudyInstanceUID}/${BulkDataURI}`;
     } else if (
       isInstanceStart ||
-      dicomWebConfig.bulkDataURI?.relativeResolution === 'series' ||
-      !dicomWebConfig.bulkDataURI?.relativeResolution
+      uriConfig.relativeResolution === 'series' ||
+      !uriConfig.relativeResolution
     ) {
       value.BulkDataURI = `${dicomWebConfig.wadoRoot}/studies/${StudyInstanceUID}/series/${SeriesInstanceUID}/${BulkDataURI}`;
     }
     return;
   }
 
+
   // in case it is relative path but starts at the server (e.g., /bulk/1e, note the missing http
   // in the beginning and the first character is /) There are two scenarios, whether the wado root
   // is absolute or relative. In case of absolute, we need to prepend the wado root to the bulkdata
diff --git a/platform/app/public/config/local_orthanc.js b/platform/app/public/config/local_orthanc.js
index 14c4b6d9c..0398a2f3c 100644
--- a/platform/app/public/config/local_orthanc.js
+++ b/platform/app/public/config/local_orthanc.js
@@ -14,11 +14,11 @@ window.config = {
   showCPUFallbackMessage: true,
   strictZSpacingForVolumeViewport: true,
   // filterQueryParam: false,
-  defaultDataSourceName: 'dicomweb',
+  defaultDataSourceName: 'orthanc',
   dataSources: [
     {
       namespace: '@ohif/extension-default.dataSourcesModule.dicomweb',
-      sourceName: 'dicomweb',
+      sourceName: 'orthanc',
       configuration: {
         friendlyName: 'local Orthanc DICOMWeb Server',
         name: 'DCM4CHEE',
@@ -37,6 +37,17 @@ window.config = {
         omitQuotationForMultipartRequest: true,
         bulkDataURI: {
           enabled: true,
+          // This is an example config that can be used to fix the retrieve URL
+          // where it has the wrong prefix (eg a canned prefix).  It is better to
+          // just use the correct prefix out of the box, but that is sometimes hard
+          // when URLs go through several systems.
+          // Example URLS are:
+          // "BulkDataURI" : "http://localhost/dicom-web/studies/1.2.276.0.7230010.3.1.2.2344313775.14992.1458058363.6979/series/1.2.276.0.7230010.3.1.3.1901948703.36080.1484835349.617/instances/1.2.276.0.7230010.3.1.4.1901948703.36080.1484835349.618/bulk/00420011",
+          // when running on http://localhost:3003 with no server running on localhost.  This can be corrected to:
+          // /orthanc/dicom-web/studies/1.2.276.0.7230010.3.1.2.2344313775.14992.1458058363.6979/series/1.2.276.0.7230010.3.1.3.1901948703.36080.1484835349.617/instances/1.2.276.0.7230010.3.1.4.1901948703.36080.1484835349.618/bulk/00420011
+          // which is a valid relative URL, and will result in using the http://localhost:3003/orthanc/.... path
+          // startsWith: 'http://localhost/',
+          // prefixWith: '/orthanc/',
         },
       },
     },