60 lines
2.0 KiB
JavaScript
60 lines
2.0 KiB
JavaScript
/**
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* Calculates total lesion burden given the Trial Criteria Type.
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* Supports RECIST 1.1 and irRC at present, defaults to RECIST.
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*
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* @param criteriaType Either 'RECIST' or 'irRC'
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* @returns {*}
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*/
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calculateTotalLesionBurden = function(criteriaType) {
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var totalBurden;
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var measurements = Measurements.find({
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isTarget: true
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});
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switch (criteriaType) {
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default:
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case 'RECIST':
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// - Time Point Measurement Total =
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// Sum of long axis measurements for extranodal target lesion +
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// short axis measurements for nodal lesions
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var sumLongAxisExtranodal = 0,
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sumShortAxisNodal = 0;
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measurements.forEach(function(measurement) {
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var LD = parseFloat(measurement.longestDiameter);
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var SD = parseFloat(measurement.longestDiameter);
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if (measurement.nodal === true) {
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sumShortAxisNodal += SD;
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} else {
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sumLongAxisExtranodal += LD;
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}
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});
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totalBurden = sumLongAxisExtranodal + sumShortAxisNodal;
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break;
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case 'irRC':
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// - Time Point Measurement Total = SPD target lesions + SPD new lesions
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// (SPD = sum of product of long axis and short axis diameters)
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var sumProductLesions = 0,
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sumProductNewLesions = 0;
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measurements.forEach(function(measurement) {
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var LD = parseFloat(measurement.longestDiameter);
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var SD = parseFloat(measurement.shortestDiameter);
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var product = LD * SD;
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if (measurement.newLesion === true) {
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sumProductNewLesions += product;
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} else {
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sumProductLesions += product;
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}
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});
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totalBurden = sumProductLesions + sumProductNewLesions;
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break;
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}
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return totalBurden;
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};
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